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胡颖珺.老年高血压患者预注地佐辛抑制芬太尼呛咳反射半数有效剂量的测定[J].浙江中西医结合杂志,2017,27(9):
老年高血压患者预注地佐辛抑制芬太尼呛咳反射半数有效剂量的测定
Determination of patients with pre injection of dezocine suppress fentanyl cough reflex half effective dose of hypertension in the elderly
投稿时间:2017-02-03  修订日期:2017-02-03
DOI:
中文关键词:  讨剂量不同的地佐辛预注防止老年高血压患者注射芬太尼导致呛咳反射发生率的差异,并测定半数有效剂量。方法:58例在我院行择期手术的老年高血压患者进入手术室后常规监测平均动脉压(MAP)、心率(HR)和血氧饱和度(SPO2)。根据序贯疗法,在麻醉诱导前10 min实施地佐辛静脉注射,记录在注射不同剂量地佐辛后快速给予芬太尼出现呛咳和无呛咳反射的患者数,并记录患者入室时,预注地佐辛后10 min,快速推注芬太尼诱导后1 min的MAP、HR、SpO2值。根据Dixon序贯法,计算地佐辛抑制芬太尼诱导过程所致呛咳反射的半数有效剂量(ED50)。结果:在T3时间段,呛咳组MAP、HR值和无呛咳组比较明显较高(t=5.15、5.64,均P<0.05),也明显高于组内T1时间段MAP、HR值(t=4.85、5.33,均P<0.05)。地佐辛抑制芬太尼呛咳反射ED50为0.0528 mg/kg,地佐辛预注剂
英文关键词:hypertension  elderly  Zosin  fentanyl  cough reflex  median effective dose
基金项目:
作者单位E-mail
胡颖珺 桐庐一院 13362182022@126.com 
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中文摘要:
      【】目的:探讨剂量不同的地佐辛预注防止老年高血压患者注射芬太尼导致呛咳反射发生率的差异,并测定半数有效剂量。方法:58例在我院行择期手术的老年高血压患者进入手术室后常规监测平均动脉压(MAP)、心率(HR)和血氧饱和度(SPO2)。根据序贯疗法,在麻醉诱导前10 min实施地佐辛静脉注射,记录在注射不同剂量地佐辛后快速给予芬太尼出现呛咳和无呛咳反射的患者数,并记录患者入室时,预注地佐辛后10 min,快速推注芬太尼诱导后1 min的MAP、HR、SpO2值。根据Dixon序贯法,计算地佐辛抑制芬太尼诱导过程所致呛咳反射的半数有效剂量(ED50)。结果:在T3时间段,呛咳组MAP、HR值和无呛咳组比较明显较高(t=5.15、5.64,均P<0.05),也明显高于组内T1时间段MAP、HR值(t=4.85、5.33,均P<0.05)。地佐辛抑制芬太尼呛咳反射ED50为0.0528 mg/kg,地佐辛预注剂量为0.07 mg/kg时所有患者均未见呛咳反应。结论:地佐辛抑制芬太尼快速诱导过程中所致呛咳反射ED50为0.0528 mg/kg,保持这个剂量可以使芬太尼诱导过程中所致的呛咳反射明显减少,保持血流动力学相对稳定,无明显抑制呼吸功能。
英文摘要:
      Objective: To investigate the different doses of dezocine pre injection to prevent the elderly hypertensive patients were injected with fentanyl cause choking cough reflex occurrence rate differences, and the median effective dose were measured. Methods: 58 elderly patients with hypertension undergoing elective surgery in our hospital were monitored with mean arterial pressure (MAP), heart rate (HR) and blood oxygen saturation (SPO2) after entering the operation room. According to the sequential therapy, in the 10 min before induction of anesthesia implementation of dezocine intravenous recorded after the injection of different doses of dezocine rapid fentanyl appear cough and no irritating cough reflex patients number, and record the patients when entering the room, 10 min after pre injection of dezocine quickly push injection of fentanyl induced after 1 min of map, HR, SpO2 values. According to the Dixon sequential method, calculation of dezocine suppress fentanyl induced process caused by choking cough reflex the median effective dose (ED50). Results: during the period of T3, the MAP, HR value and non choking cough group were significantly higher (t=5.15, 5.64, P < 0.05), and were significantly higher than that in group MAP, T1, HR (t=4.85, 5.33, P < 0.05). Dezocine suppresses fentanyl choking cough reflex ED50 for 0.0528 mg / kg, dezocine priming dose is 0.07 mg / kg in all patients were no choking cough response. Conclusion: dezocine inhibition of fentanyl induced rapid process caused by choking cough reflex ED50 for 0.0528 mg / kg, keep the dose can make the fentanyl induced process induced cough reflex was significantly reduced, maintain the relative stability of the hemodynamic and no obviously inhibited the respiratory function.
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