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陈灵红,林红霞,杨德华.血清淀粉样蛋白A在川崎病诊断中的临床应用价值[J].浙江中西医结合杂志,2017,27(9):
血清淀粉样蛋白A在川崎病诊断中的临床应用价值
Role of Serum Amyloid A in Patients with Kawasaki Disease
投稿时间:2017-02-03  修订日期:2017-03-09
DOI:
中文关键词:  川崎病  血清淀粉样蛋白A  冠状动脉损伤
英文关键词:Kawasaki Disease  Serum Amyloid A  Coronary artery lesion
基金项目:温岭市科技计划项目(2012WLCA0057)
作者单位E-mail
陈灵红 浙江省温岭市第一人民医院 浙江 台州 364037383@qq.com 
林红霞 浙江省温岭市第一人民医院  
杨德华 浙江大学医学院  
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中文摘要:
      【】 目的 探讨血清淀粉样蛋白A在川崎病患儿中的变化和临床应用价值。方法 58 例川崎病患儿,根据病程长短分为急性期和亚急性期,采集静脉血,采用纳米金法检测血清淀粉样蛋白A水平,并与同期非川崎病引起的发热患儿60 例(对照组)进行对照分析。根据冠状动脉损伤情况,将川崎病分为冠状动脉损伤组和无冠状动脉损伤组,比较两组血清淀粉样蛋白A的水平。结果 川崎病急性期血清淀粉样蛋白A浓度(291.05±170.21) mg/L明显大于亚急性期组(4.93±2.23) mg/L和对照组(74.26±52.68) mg/L (p<0.01)。川崎病急性期血清淀粉样蛋白A 100%异常,显著高于亚急性期组和对照组(p<0.01)。冠状动脉损伤组血清淀粉样蛋白A水平为(247.33±183.36 mg/L),无冠状动脉损伤组(213.14±197.10 mg/L),两组比较无显著性差异(p=0.559)。结论 川崎病患儿急性期血清血清淀粉样蛋白A水平升高,亚急性期下降,对于早期诊断川崎病具有较大的临床应用价值。
英文摘要:
      【】 Objective To investigate the expression level of Serum amyloid A (SAA) in Kawasaki Disease (KD) and evaluate it as a diagnostic biomarker that can be used to facilitate earlier diagnosis of KD. Methods A prospective study was performed among 58 children with KD, 60 febrile control subjects. The levels of SAA was detected and analyzed. Results The SAA was upregulated during the acute phase in patients with KD (291.05±170.21) mg/L when compared with subacute KD (4.93±2.23) mg/L and the febrile control (74.26±52.68) mg/L (p < 0.01). The proportion of abnormal SAA for acute KD patients were significantly higher than those in the other group (p < 0.01). The SAA levels for coronary artery lesion were (247.33±183.36) mg/L and (213.14±197.10) mg/L in non-coronary artery lesion. Conclusions SAA is elevated in the plasma of acute KD when compared with subacute KD and febrile control subjects. It suggests SAA may be a biomarker to facilitate KD diagnosis.
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